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IntroductionPast studies have connected physical activity (PA) and Parkinson's disease (PD) to chronic inflammation. We use DNA methylation-derived (DNAm) proxies for inflammation to investigate the relationship between PA and chronic inflammation among PD patients.MethodsWe collected demographics, lifestyle, and PA status information by interviewing 555 PD patients enrolled in the Parkinson's Environment and Gene (PEG) studies. We used the epigenetic clock website to generate DNAm proxies and performed principal component analysis (PCA) of 22 DNAm cytokine proxies. Using the Mann-Whitney U test, we compared the PC scores of active and sedentary patients. For PCs associated with PA status, we examine associations between PA status, the amount of PA, and PCs for DNAm cytokines using permutation-based tests.ResultsCompared to sedentary PD patients, those who reported strenuous PA have lower levels of c-reactive protein (CRP; p ConclusionPA may benefit PD patients by reducing chronic inflammation. We also found that strenuous PA may increase the proportions of NK and CD8T cells, though further effort is needed to confirm potential shifts in immune cell subtypes.
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