Assessing prevalence and risk factors for REM sleep behavior disorder among patients with inflammatory bowel disease.

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REM sleep behavior disorder (RBD) and inflammatory bowel disease (IBD) are associated with Parkinson's Disease. Using a cross-sectional design, we assessed RBD prevalence in IBD and controls. In total, 158 controls and 462 IBD patients completed IBD-related history questionnaires, the RBD Single-Question Screen (RBD1Q), and the RBD-Screening Questionnaire. RBD prevalence was compared using chi-squared testing. Logistic regression explored IBD-related factors associated with RBD (RBD1Q), adjusting for age, sex, race, and antidepressant usage. RBD prevalence was higher in IBD (14.1% vs. 5.1%; P = 0.002), driven by differences in women; 13.3% IBD and 1.0% controls had RBD. Among men, 16.0% IBD and 11.9% controls had RBD. IBD was associated with >threefold RBD odds (OR = 3.08, 95% CI [1.43, 6.62], P = 0.003). Men with RBD and IBD had higher IBD-related hospitalization rates than IBD males without RBD (95.2% vs. 63.0%; P = 0.004). RBD is more prevalent in IBD than in controls and is associated with severe IBD.

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