NeuralCipher Research overview
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ObjectiveTo evaluate the feasibility of a 12-week community-based, non-contact rock-steady-boxing (RSB) program in individuals with Parkinson disease (PD) and to assess potential improvements in motor and cognitive functioning after intervention.MethodOver 12 weeks, 26 PD participants completed 24 RSB classes. Motor and cognitive assessments were conducted at baseline and follow-up, with a sub-group (n = 14) wearing clinical actigraphy. Linear mixed-effects models investigated compliance and changes in motor and cognitive functions. Multiple linear regression assessed correlations of clinical changes with clinicodemographic factors and actigraphy variables (two-sided p ResultsPD participants showed significantly improved motor performance on the Mini Balance Evaluation Systems Test following RSB (p ConclusionsRSB intervention led to better motor functioning and potential, though uncertain, cognitive benefits independent of age, sex, or disease severity. Cautious interpretation of exploratory analyses suggests changes in activity and sleep may relate to motor and cognitive changes following RSB. Findings support compliance with RSB in PD and motivate larger, randomized trials investigating the role of exercise in facilitating PD symptom improvement.
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