NeuralCipher Research overview
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RationaleParkinson disease (PD) is characterized by bradykinesia, resting tremor, rigidity, as well as other motor and non-motor symptoms due to damage to dopaminergic neurons in the substantia nigra. Holmes tremor (HT), otherwise, manifests itself as resting, intentional, and postural tremors in the limbs, resulting from lesions in the red nucleus of the midbrain. These 2 distinctive maladies seldom emerge simultaneously. This study delineates a case with both PD and HT occurring after vertebrobasilar dolichoectasia.Patient concernsA 54-year-old male patient experienced a gradual aggregation of static and kinetic postural tremors in the last 2 years.DiagnosisBrain magnetic resonance imaging revealed vertebrobasilar dolichoectasia compressing the midbrain, whereas intracranial ultrasound confirmed the diagnosis of PD.InterventionsThe patient received long-term medication with levodopa and benserazide hydrochloride tablets, pramipexole hydrochloride, and trihexyphenidyl.OutcomesThe tremor was resolved, and the quality of life was improved substantially.LessonsIn patients with both PD and HT, the identification of underlying causes and the proper symptomatic treatment are crucial for relieving the symptoms. However, the ultimate approaches would be microvascular decompression, deep-brain stimulation, or stereotactic thalamotomy.
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