NeuralCipher Research overview
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Immune dysregulation is involved in Parkinson's disease (PD), but the roles of C-X-C motif chemokine receptor 3 (CXCR3)/chemokine receptor 6 (CXCR6) on T cells and their correlation with peripheral inflammation remain unclear. This study investigated their expression on peripheral blood T cells and correlation with inflammation in PD. A total of 36 PD patients and 26 healthy controls were enrolled; their clinical information and laboratory test results (including the systemic immunoinflammatory index [SII], neutrophil-to-lymphocyte ratio [NLR], monocyte-to-lymphocyte ratio [MLR], platelet-to-lymphocyte ratio [PLR], monocyte-to-high-density lipoprotein ratio [MHR], and erythrocyte distribution width over platelets ratio [RPR]) were recorded. Meanwhile, a multicolour flow cytometry protocol using six cell surface antibodies (CD3, CD4, CD8, CD45RO, CXCR3, and CXCR6) was applied. The results showed that CD8+ T cells were significantly reduced in the PD group compared with healthy controls (p + effector T cells and CD8+ T cells of PD patients (p + T cells between PD patients and controls (p > 0.05). Compared with healthy controls, PD patients had significantly increased peripheral blood C-reactive protein (CRP) levels (p + T lymphocytes may contribute to PD pathogenesis, though no significant correlation between the expression of these receptors and peripheral inflammation was observed.
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