NeuralCipher Research overview
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ObjectiveThis exploratory study aimed to investigate whether ultrasound shear wave elastography (SWE) could quantify rigidity in Parkinson's disease (PD) and assess potential biomechanical differences between the brain-first and body-first subtypes.MethodsShear wave elastography was used to measure the Young's modulus (YM) and shear wave velocity (SWV) of the biceps brachii in 70 healthy controls (HCs) and 102 patients with PD (40 classified as body-first, 62 classified as brain-first based on RBDSQ criteria). Group comparisons were conducted using t-tests or ANOVA, correlations were assessed via Pearson or Spearman tests, and diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis.ResultsYoung's modulus and SWV values were significantly higher in PD patients than in HCs (all p p p ConclusionShear wave elastography is a sensitive tool for quantifying rigidity in PD. This pilot study provides the first evidence of a significant difference in muscle biomechanical properties between PD subgroups classified according to current clinical criteria. While SWE shows promise as a supplementary biomarker, its integration with established subtyping markers (e.g., polysomnography, MIBG scintigraphy) in future multimodal and longitudinal studies is essential to determine its role in clinical subtyping.
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