NeuralCipher Research overview
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BackgroundWe aimed to compare agitation severity in dementia with versus without delirium (DSD vs. DwD); to identify clinical factors linked to agitation severity; and to examine psychotropic prescribing patterns, including clinical correlates.MethodsWe retrospectively analysed 1709 consecutive patients with dementia admitted to acute geriatric units, comparing those with and without delirium. Delirium and dementia were identified from discharge diagnoses documents. Agitation severity was assessed with the Pittsburgh Agitation Scale (PAS) during the first 72 h. Functional status at admission was documented according to the Functional Independence Measure (FIM). Psychotropic exposure included antipsychotics and benzodiazepines. Multivariable linear regressions examined associations between psychotropics and PAS; logistic regressions identified predictors of psychotropic prescribing.ResultsDSD occurred in 680 patients (39.8%). Compared with dementia alone, DSD was associated with higher PAS scores (5.3 vs. 4.0, p ConclusionDSD was linked to more severe agitation and psychotropic use. These findings support PAS-based monitoring and development of DSD-specific interventions prioritising non-pharmacological strategies.
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