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SCIENTIFIC LITERATURE · MED

Carbidopa/levodopa induced severe vitamin B6 deficiency leading to symptomatic transfusion dependent microcytic Anemia.

Oxf Med Case Reports · 2026-04-28

DOI: 10.1093/omcr/omaf191PMID: 42057972

Open accessJournal Article; Case Reports; case-reportOriginal source ↗

Research overview

The text below is the source article’s original abstract under a verified reuse license. cc by

Parkinson's Disease is on the rise over the coming decades with expectations that more patients will be prescribed levodopa therapy. This case presents a patient with Parkinson's Disease who presented with severe symptomatic microcytic anemia. He was transfusion dependent during his extensive work up that occurred during both inpatient hospitalization and outpatient hematology visits. This was negative for iron deficiency, infectious etiology, hemolysis, active bleeding, bone marrow failure, myelodysplasia or hematologic malignancy. However, patient was found to have a critically low vitamin B6 level. Following initiation of vitamin B6 supplementation, patient's anemia resolved and was no longer transfusion dependent.

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