NeuralCipher Research overview
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•VPS13C parkinsonism showed initial STN-DBS benefit then rapid decline.•Motor, cognitive, and psychiatric deterioration occurred after DBS.•Cardiac MIBG converted from normal uptake to denervation over 7 years.•Findings support genetic testing before DBS in early-onset PD.•Surgicogenomics may guide DBS candidate selection in genetic PD.
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