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BackgroundAerobic exercise is beneficial in managing Parkinson disease (PD), yet its potential remains less clear in early stages. This study investigates the impact of long-term aerobic exercise habits in individuals with early-stage PD compared with healthy controls.DesignCross-sectional study.ObjectivesTo evaluate whether long-term exposure to moderate- to high-intensity exercise was associated with more favorable physical, cognitive, and patient-reported outcomes in early PD, by comparing "highly active" individuals (self-reported moderate- to high-intensity aerobic exercise ≥ twice weekly for >3 months) with "low-active" individuals (self-reported moderate- to high-intensity aerobic exercise ≤ twice weekly for >3 months) and healthy controls.SettingUniversity.ParticipantsSeventy low-active individuals with PD, 35 highly active individuals with PD, and 35 healthy controls were included.InterventionsNot applicable.Main outcome measure(s)Assessments included Timed Up and Go Test, Six Spot Step Test, 6-Minute Walk Test, Mini Balance Evaluation Systems Test, Lower Extremity Muscle Peak Power, Aerobic Capacity, Physical Activity, Montreal Cognitive Assessment, Symbol Digit Modalities Test, Parkinson's Disease Questionnaire, Non-Motor Symptoms Questionnaire, Falls Efficacy Scale-International, European Quality of Life Questionnaire, Beck Depression Inventory-II, and Movement Disorders Society-sponsored revision of the Unified Parkinson's Disease Rating Scale.ResultsHighly active individuals with PD outperformed low-active individuals with PD (p ConclusionsRegular engagement in moderate- to high-intensity aerobic exercise in early PD may preserve physical function, suggesting a potential role in limiting disease-related motor decline. These findings support the consideration of early, high-intensity aerobic exercise interventions as part of a comprehensive management strategy for PD.
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