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BackgroundParkinson's disease (PD) is a complex neurodegenerative disorder characterized by both motor and non-motor symptoms, with autonomic dysfunction significantly impacting patients' quality of life. Despite its recognized importance, comprehensive evaluation of autonomic dysfunction in PD remains limited.ObjectiveTo assess cardiovascular autonomic dysfunction in PD, explore its association with disease severity, and examine the modulatory effects of dopaminergic therapy.MethodsA cross-sectional study was conducted involving 60 PD patients and 30 age- and sex-matched healthy controls. Autonomic function was evaluated using standardized cardiovascular tests, including deep breathing, the Valsalva maneuver, and head-up tilt. Heart rate variability, baroreflex sensitivity, and orthostatic blood pressure responses were measured. Parkinson's disease patients were evaluated in both dopaminergic medication ON and OFF states. Correlations between autonomic parameters and disease severity were analyzed.ResultsParkinson's disease patients demonstrated significant autonomic impairment compared to controls (p p = 0.032), baroreflex sensitivity (p = 0.041), and orthostatic response (p = 0.025).ConclusionParkinson's disease patients exhibit marked cardiovascular autonomic dysfunction correlating with disease severity. The modest modulatory effects of dopaminergic medication on autonomic parameters suggest complex dopaminergic-autonomic interactions and supports autonomic parameters as potential markers of disease progression.
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