NeuralCipher Research overview
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ObjectiveThe purpose of this study is to ascertain the incidence of fatigue and to determine the cross-sectional associate and related variables of fatigue in patients with Parkinson's disease (PD).MethodsA sample of 130 healthy individuals (39.23% male, mean age 64.19 ± 8.70 years) and 130 patients with PD (50.00% males, mean age 65.06 ± 9.04) were enrolled in the study. All participants were evaluated using the Fatigue Severity Scale (FSS), Mini-Mental State Examination (MMSE), Hamilton anxiety scale (HAMA), and Hamilton depression scale (HAMD). Patients with PD were assessed with the Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn & Yahr staging, the MMSE, HAMA, HAMD, the Parkinson's Disease Sleep scale-2 (PDSS-2), and Parkinson's Disease Questionnaire-39 (PDQ-39).ResultsThe PD group exhibited significantly higher scores in the FSS (p p = 0.003). Patients experiencing fatigue exhibited significantly higher scores on the UPDRS (p p 0.001), NMSS (p p p p = 0.012), and PDQ-39 (p ConclusionPatients with Parkinson's disease experience a higher incidence of distressing fatigue compared to healthy individuals. The significant prevalence of fatigue among these patients is linked to various motor and non-motor symptoms.
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