Highly Repeatable Fibrous Crack-Based Strain Sensor for Multichannel Continuous Tremor Monitoring in Parkinson's Disease and Essential Tremor.

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Objective measurement of tremors is important for assessing the severity and preventing misdiagnosis of Parkinson's disease (PD). To address this demand, this study presents a multichannel, wireless, patch-type tremor monitoring system that integrates a high-repeatable fibrous crack-based strain (FCBS) sensor with a flexible wireless communication circuit. The FCBS sensor, incorporating crack structures, random fiber orientation, junction melting, and polymer penetration within a 3D conductive fiber network, achieves high sensitivity (gauge factor up to 476.89), a fast response time (≈ 6.64 ms), a wide working range (>200% strain), low Young's modulus (≈45 kPa), and excellent repeatability (>100 000 cycles). In addition, this study demonstrates the first clinical application of a flexible strain sensor-based tremor monitoring system in patients with PD and ET for simultaneous multilocation tremor measurement. Through clinical trials, our system measured tremor indicators (peak amplitude and fundamental frequency), and tremor indicators obtained from multilocation showed improved correlation and statistical significance with tremor scoring in UPDRS III under specific conditions. These results demonstrate the applicability and potential of the flexible strain sensor-based system as a wearable platform for quantitative and objective tremor measurement.

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