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SCIENTIFIC LITERATURE · MED

Parkinson's gut dysmotility: A role for DMV cholinergic neurons.

Cell Rep · 2026-09-09

DOI: 10.1016/j.celrep.2026.117909PMID: 42715097

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Research overview

The text below is the source article’s original abstract under a verified reuse license. cc by

Yu and colleagues1 demonstrate that α-synuclein pathology within the dorsal motor nucleus of the vagus (DMV) compromises neuronal excitability and drives Parkinson's disease-related gastrointestinal dysmotility through alteration of a fundamental DMV-gut circuit. Electroacupuncture reactivates this circuit ameliorating this functional deficit.

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