Prior Parkinson's disease diagnosis and subsequent self-reported psychological resilience in the UK Biobank.

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BackgroundThe association between psychological resilience and Parkinson's disease (PD) remains unclear at the population level.MethodsWe analyzed 147,143 UK Biobank participants with available Brief Resilience Scale (BRS) data and complete covariate information. Parkinson's disease was ascertained using a previously published UK Biobank algorithm. Multivariable logistic regression was used to examine the association between subsequently assessed BRS scores and prior PD after adjustment for demographic, socioeconomic, lifestyle, clinical, and genetic factors. Restricted cubic splines were used to assess nonlinearity.ResultsThe mean age was 55.3 years, 56.4% of participants were women, and 346 (0.24%) had Parkinson's disease. Higher subsequently assessed BRS scores were associated with lower odds of a prior Parkinson's disease diagnosis. In the fully adjusted model, each 1-point increase in BRS was associated with an OR of 0.63 (95% CI, 0.55-0.73; p p ConclusionPrior Parkinson's disease diagnosis was associated with lower subsequently assessed self-reported psychological resilience in the UK Biobank. Given the observational design, causality cannot be established.

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