NeuralCipher Research overview
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Parkinson's disease (PD) is characterized by motor dysfunction and dopaminergic neuron loss and is influenced by genetic and environmental factors. Here, we evaluated hydrogen peroxide (H₂O₂) as an accessible oxidative stress model of PD in Drosophila larvae. High H₂O₂ concentrations caused lethality or severe developmental impairment, whereas animals exposed to 0.005-0.025% H₂O₂ progressed through larval development and to pupation. Pupation timing was similar to untreated controls at 0.005% and 0.01% H₂O₂ but was delayed by 0.025% H₂O₂. Low-dose H₂O₂ reduced crawling speed and impaired navigational performance but did not cause detectable dopaminergic neuron loss or exacerbate locomotor deficits associated with A53T α-synuclein expression. Thus, H₂O₂ produces behavioral effects without fully recapitulating PD pathology and provides an accessible model for investigating developmental oxidative stress and its potential long-term consequences.
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