NeuralCipher Research overview
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Variants in PGLYRP2 , particularly rs892145-T, have been suggested as Parkinson’s disease (PD) risk factors. We analyzed data from 48,458 PD patients and 24,670 controls across diverse ancestries. Contrary to previous findings on smaller datasets, no significant sex-dependent effect of rs892145-T was observed across all ancestries. Gene-based analyses identified another variant, rs959117-T, as nominally associated with PD in AAC females (OR=0.65, 95%CI:0.50-0.85, p=1.70E-03), but it did not survive correction for multiple testing (Bonferroni p=0.10). Overall, our results show no association between PGLRYP2 and PD. Highlights No significant association was found in burden analysis between PGLYRP2 and PD. Sex-stratified analysis showed no association between rs892145-T and PD across all ancestries. The rs959117-T genetic variant might provide a protective effect against PD in females of African American and Caribbean ancestry.
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