NeuralCipher Research overview
The text below is the source article’s original abstract under a verified reuse license. cc by
Abstract Objective To investigate the effects of rasagiline combined with donepezil on oxidative stress injury, cognitive function, and serum brain-derived neurotrophic factor (BDNF) levels in patients with Parkinson’s disease (PD). Methods A total of 188 PD patients admitted to our hospital between October 2021 and October 2024 were enrolled and randomly assigned to either the control group (n = 94, treated with donepezil hydrochloride) or the combination group (n = 94, treated with rasagiline in addition to donepezil hydrochloride) using the random number table method. Both groups received continuous treatment for 4 months. Clinical efficacy and incidence of adverse events were compared between groups. Mini-Mental State Examination (MMSE) scores, Montreal Cognitive Assessment (MoCA) scores, serum malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), and BDNF levels were measured before and after treatment. Motor function was assessed using the Fugl-Meyer Assessment (FMA), daily living ability using the Barthel Index, and overall motor symptoms using the Webster Scale. Results The total clinical response rate was significantly higher in the combination group than in the control group (P 0.05). Conclusion Rasagiline combined with donepezil yields superior clinical efficacy in PD patients, effectively attenuating oxidative stress injury, increasing serum BDNF levels, and improving both cognitive and motor function, with a favorable safety profile. This regimen represents a promising therapeutic option for PD management.
Scientific assessment
Research question
Assess the question within the original study’s scope.
Methods & sample
Check the source article for study design and sample details.
Key findings
An editorially approved findings summary is not yet published for this record.
Limitations
Generalizability, bias and clinical meaning require separate assessment.
Methods, samples and clinical conclusions are not inferred from bibliographic metadata.