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Abstract Objective This study aimed to investigate changes in cerebral hemodynamics in Parkinson’s disease (PD) patients using cerebrovascular hemodynamic detection (CVHD) and transcranial Doppler (TCD), and to explore the associated influencing factors. Methods We enrolled 75 PD patients admitted to the Department of Neurology, Third Hospital of Hebei Medical University, from January 2022 to March 2024, along with 50 healthy controls matched for the same period. General clinical data of PD patients were collected, and motor function, disease severity, and autonomic function were evaluated using the Unified Parkinson’s Disease Rating Scale Part III (UPDRS III), Hoehn-Yahr (H-Y) staging, and Scales for Outcomes in Parkinson’s Disease-Autonomic (SCOPA-AUT). CVHD-derived total cerebral function scores and TCD parameters of the middle cerebral artery (MCA), including peak systolic velocity (Vs), end-diastolic velocity (Vd), mean velocity (Vm), and pulsatility index (PI), were recorded for all participants. Clinical data and examination results were compared between the two groups, and clinical factors influencing cerebral function scores in PD patients were analyzed. Results Compared with healthy controls, PD patients exhibited a significant reduction in total CVHD cerebral function scores (t=-9.217, P 0.05). In PD patients, UPDRS III scores, SCOPA-AUT scores, and H-Y stages were negatively correlated with cerebral function scores (r=-0.842, -0.498, -0.301; all P
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