NeuralCipher Research overview
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Abstract Cognitive impairment (CI) is common in Parkinson’s disease (PD), affecting up to 30% of patients at diagnosis and increasing over time. This study evaluated and compared existing risk prediction tools for screening mild cognitive impairment (MCI) and assessing risk of subsequent cognitive decline in people with PD by validating and extending them with PD-specific and modifiable risk factors. Data from 201 PwPD and 231 controls from the Luxembourg Parkinson’s study were analyzed; 46.77% of PwPD had MCI. The Lifestyle for Brain Health (LIBRA) and preliminary disease Risk Estimator for Decline in Cognition Tool (pPREDICT) risk scores were evaluated and expanded to create a new tool called “ Modi fiable factors for cog nitive decline in PD” (ModiCogPD), and predictive performance was assessed using ROC–AUC, logistic regression, and Cox models. PD-specific scores (pPREDICT and ModiCogPD) showed better performance than LIBRA, with higher scores associated with increased risk of cognitive decline over time, while LIBRA was more informative in early disease stages.
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