Two SNPs (rs1801282 and -1279G/A) of PPARγ are associated with Parkinson's disease in a northern Chinese population

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Abstract Background: This study aimed to assess the association between PPARγ gene polymorphism and susceptibility to Parkinson’s disease (PD) in a northern Chinese population. Methods : We conducted a case-control study which including 391 outpatients with PD and 391 healthy matched individuals. All subject genotypes on PPARγ gene in rs3856806, rs1801282, -1279G/A were determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. Results : Our results showed participants with AG and AG+AA (dorminant model) genotypes of -1279G/A had a higher genetic risk of PD compared to those with GG ( p = 0.024, OR = 1.781, 95% CI = 1.073-2.956; p = 0.024,OR = 1.768, 95% CI = 1.078-2.898). A allele of the -1279G/A polymorphism was presumably correlated with increased risk of PD ( p = 0.037,OR = 1.639, 95% CI = 1.027-2.616) and male PD ( p =0.032, OR = 1.998, 95% CI = 1.051-3.798) as well as early-onset Parkinson’s disease (EOPD)( p =0.019, OR = 2.667, 95% CI = 1.263-5.629). Stratification analysis by age for rs1801282 indicated a significant genotype difference between EOPD and controls( p =0.005) as well as late-onset Parkinson’s disease(LOPD) and controls( p =0.008). G allele frequency of rs1801282 in EOPD subjects was significantly higher than it in controls( p = 0.006, OR =3.093, 95% CI = 1.446-6.615) and LOPD ( p = 0.009, OR =2.899, 95% CI = 1.344-6.253). Conclusions : The study showed that in a northern Chinese population, the A allele of -1279G/A might be a risk factor for PD and the G alle of rs1801282 might increase the susceptibility of EOPD.

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