NeuralCipher Research overview
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Abstract Background. Upper limb sensorimotor dysfunction in Parkinson's Disease (PD) is poorly captured by existing clinical assessments, which lack sensitivity to movement quality and do not capture within-session variability. The Virtual Peg Insertion Test (VPIT) is a previously developed technology-based assessment capable of quantifying movement smoothness, speed, efficiency, and grip force control during a goal-directed task, but its feasibility and validity in PD have not yet been established. Methods. Eight patients with PD underwent baseline VPIT testing with five VPIT repetitions per hand alongside conventional motor assessments. The protocol comprised four sessions over 12 months (baseline, 3, 6, 12 months). Feasibility, usability, convergent validity, within-session variability, and longitudinal trajectories were assessed against an age- and gender-matched normative database (n = 124). Results. Three of eight patients (37.5%) could not complete the VPIT at baseline, with task failure linked to low MoCA visuospatial subscores rather than motor severity. Retention among completers was 100%. PD patients showed significant impairment in movement speed (one-sample Wilcoxon signed-rank test, d = −1.84, p
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