NeuralCipher Research overview
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The beta oscillations of the human primary sensorimotor cortex (SM1) play a crucial role in regulating motor and cognitive behavior in health and disease. However, their assessment relies on costly and complex neuroimaging techniques, limiting scalability and translational applications. We present a novel method for assessing beta oscillations from easily obtained peripheral electromyography and force recordings. We show that movement-induced modulations in SM1 beta oscillations can be assessed from the electromyography or force recordings of a contracted contralateral hand muscle. We demonstrate the fidelity of this method in young and elderly healthy participants and in Parkinson’s disease patients. We also demonstrate that the resting-state SM1 beta interhemispheric coupling can be assessed from an interhand coupling between the electromyography or force of contracted homologous hand muscles. This methodology enables scalable and cost-effective investigations of beta oscillations for all fields of human neuroscience and for the development of accessible disease/therapeutic markers.
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