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Abstract Background : Epidemiological data on the comorbidity burden of Parkinson's disease (PD) in Southwest China are limited [1]. This study evaluated the comprehensive comorbidity burden among hospitalized patients with PD or secondary parkinsonism in this region. Methods : A retrospective cross-sectional study was conducted using inpatient records from Sichuan Provincial People's Hospital between May 2018 and August 2021. Primary PD (G20) and secondary parkinsonism (G21) were identified using ICD-10 codes [2]. Comorbidities were classified using a modified framework combining the Charlson Comorbidity Index (CCI) and the Elixhauser Comorbidity Index (ECI) [3,4]. Binary logistic regression was used to estimate cross-sectional associations. Results : The study evaluated 1,457 PD patients (1,050 primary; 407 secondary) alongside 2,100 matched non-PD controls. PD patients exhibited a significantly higher comorbidity burden than controls (mean comorbidities: 2.8 for primary PD, 3.6 for secondary parkinsonism, and 2.1 for the control group). The most prevalent comorbidities were cerebrovascular disease, hypertension, and peripheral vascular disease. Both PD subtypes showed strong cross-sectional associations with depression, dementia, and cerebrovascular disease (p Conclusion : Hospitalized patients with primary PD or secondary parkinsonism had a higher recorded comorbidity burden than non-PD inpatients, with particularly strong cross-sectional associations with depression, dementia, and cerebrovascular disease. These findings describe co-occurrence and do not establish temporal or causal relationships.
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