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SCIENTIFIC LITERATURE · PPR

S-nitrosylation-impaired autophagy: An alternative mechanism underlying aging?

· 2013-11-26

DOI: 10.7287/peerj.preprints.121v1

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Research overview

The text below is the source article’s original abstract under a verified reuse license. cc by

Aging is mysterious with unknown managing patterns. A surprising finding on the tune mode of autophagy by S-nitrosylation is a distinctive step towards the interpretation of the mechanism underlying aging and age-related diseases. This commentary article will discuss, in a wider sense, the implications of S-nitrosylation- and nitration-switched dysfunction of proteins/enzymes in neurodegenerative disorders including Alzheimer's disease (AD), Huntington's diseases (HD) and Parkinson's disease (PD).

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