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Abstract Background Parkinson’s disease (PD) is associated with motor and behavioral dysfunctions. Mitochondrial damage, increased oxidative stress, and the formation of Lewy bodies by misfolded proteins are major pathways for the development of PD. Using antioxidants could delay neurodegeneration in parkinsonism and improve the symptoms. We investigated the neuroprotective effects of quercetin, curcumin, and their combination on the rotenone-induced parkinsonism model. Methods PDwas induced by administration of rotenone 2mg/kg/day for 14 days in rats. Curcumin (100, 150, and 200 mg/kg), quercetin (30, 40, and 50 mg/kg),or their combination were given orally for 14 days concurrently with rotenone and for additional 14 days. On the 28th and 29th days, behavioral and histological studies were carried out. Results In the rotenone-induced parkinsonism model, curcumin and quercetin dose-dependently improved locomotor activity, motor coordination, and mobility. Also, they increased dopamine levels and mitigated the neural damage induced by rotenone. Conclusion Both curcumin and quercetin have neuroprotective effects against parkinsonism. The combination of curcumin and quercetin has more favorable effects than usingeither drug alone.
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