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SCIENTIFIC LITERATURE · PPR

Gentiopicroside—The Biologically Active Plant Metabolite—An Insight into Its Pharmacological Significance and Future Perspectives

· 2023-10-23

DOI: 10.20944/preprints202310.1375.v1

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Research overview

The text below is the source article’s original abstract under a verified reuse license. cc by

Gentiopicroside (GPS) is a leading component of several plant species from Gentianaceae botanical family. As a compound with plenty biological activities and a component that is often consumed in dietary supplements and herbal drugs, GPS has an important role in the regulation of physiological processes in humans. Recent studies on the type 2 receptors shed new light on GPS applications showing its agonistic properties that could be meaningful in the future therapeutic strategies of Parkinson’s disease, thyroid disorders or cancer states. This review aims to collect previously published reports on the biological properties of GPS as a single compound that were confirmed by in vitro and in vivo studies, and to draw attention at the newly discovered role of this bitter-tasting secoiridoid as a type 2 receptor agonist. Thanks to these properties, the research on this substance could be revisited.

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