NeuralCipher Research overview
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Abstract Background Multiple system atrophy (MSA) and Parkinson’s disease (PD) have clinical overlapping symptoms, which makes differential diagnosis difficult. Our research aimed to distinguish MSA from PD using corneal confocal microscopy (CCM), a noninvasive and objective test. Methods The study included 63 PD patients, 30 MSA patients, and 31 healthy controls (HC). When recruiting PD and MSA, questionnaires were conducted on motor and non-motor functions, such as autonomic and cognitive functions. Participants underwent CCM to quantify the corneal nerve fibers. Results Corneal nerve fiber density (CNFD) and corneal nerve fiber length (CNFL) values in MSA are lower than PD (MSA vs. PD: CNFD, 20.68±6.70 vs. 24.64±6.43 no./mm2, p 2, p Conclusions The CCM could be an objective and sensitive biomarker to distinguish MSA from PD. It visually reflects that the degree of degeneration in MSA is more severe compared to PD.
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