Parkinson’s disease patients treated with levodopa exhibit a different pattern in the expression of emerging cytokines, IL-35 subunit and IL-37, compared to control group: A statistical analysis using Bayesian regression model

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Abstract Background Parkinson's disease (PD), is known as one of the most common neurodegenerative diseases in the world, which is characterized by the destruction of dopaminergic neurons in the substantia nigra of the midbrain. In the pathogenesis of this disease, central and peripheral inflammation play important roles. This study was done to investigate the expression of IL-35 (including P35 and Ebi3 subunits) and IL-37 genes, as well as the serum levels of IL-35 in patients with Parkinson's disease. Methods Peripheral blood samples were collected from 34 PD patients and 34 healthy individuals as a control group. IL-35 and IL-37 gene expression was measured using qRT-PCR technique and IL-35 serum level was measured by ELISA method. Advanced statistical analyzes were also performed using Bayesian regression in R software. Results The results showed that of the two subunits that make up IL-35, the expression of P35 gene was not significantly different between the two groups, while Ebi3 as well as IL-37 transcript levels were significantly lower in patients compared to healthy individuals (p 

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