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Parkinson hastalığı, Lewy cisimleri ile demans ve çoklu sistem atrofisi alfa-sinükleinopatileridir.

Parkinson's disease, dementia with Lewy bodies and multiple system atrophy are alpha-synucleinopathies.

Spillantini MG.

Parkinsonism Relat Disord · 1999-12-01

DOI: 10.1016/s1353-8020(99)00031-0PMID: 18591134

Parkinson hastalığında alfa-sinüklein immünoreaktif Lewy cisimleri ve Lewy neurites gelişmiş gümüş lekeleme tekniği ile tespit edilebilir.

Alpha-synuclein immunoreactive Lewy bodies and Lewy neurites in Parkinson's disease are detectable by an advanced silver-staining technique.

Sandmann-Keil D, Braak H, Okochi M, Haass C, Braak E.

Acta Neuropathol · 1999-11-01

DOI: 10.1007/s004010051110PMID: 10541868

Parkinson hastalığında akson patolojisi ve Lewy vücut demans hipokampusu alfa, beta ve gama-sinüklein içerir.

Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein.

Galvin JE, Uryu K, Lee VM, Trojanowski JQ.

Proc Natl Acad Sci U S A · 1999-11-01

DOI: 10.1073/pnas.96.23.13450PMID: 10557341

Alfa-Synüklein ve Parkinson hastalığı.

alpha-Synuclein and Parkinson's disease.

Burke RE.

Brain Res Bull · 1999-11-01

DOI: 10.1016/s0361-9230(99)00136-7PMID: 10643486

Fosforlu tau- ve NACP/alfa-sinüklein-epitopların sporadik Parkinson hastalığında ve Lewy vücutlarında demansta hücresel ko-lokalizasyonu.

Cellular co-localization of phosphorylated tau- and NACP/alpha-synuclein-epitopes in lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies.

Arima K, Hirai S, Sunohara N, Aoto K, Izumiyama Y, Uéda K, Ikeda K, Kawai M.

Brain Res · 1999-10-01

DOI: 10.1016/s0006-8993(99)01848-xPMID: 10528110

Ailesel Parkinsonizmde G209A alfa-sinüklein alelinin azalmış ifadesi.

Reduced expression of the G209A alpha-synuclein allele in familial Parkinsonism.

Markopoulou K, Wszolek ZK, Pfeiffer RF, Chase BA.

Ann Neurol · 1999-09-01

DOI: 10.1002/1531-8249(199909)46:3<374::aid-ana13>3.0.co;2-9PMID: 10482268

Alfa-sinüklein geni ailesel Parkinson hastalığında önemli bir risk faktörü değildir.

The alpha-synuclein gene is not a major risk factor in familial Parkinson disease.

Scott WK, Yamaoka LH, Stajich JM, Scott BL, Vance JM, Roses AD, Pericak-Vance MA, Watts RL, Nance M, Hubble J, Koller W, Stern MB, Colcher A, Allen FH, Hiner BC, Jankovic J, Ondo W, Laing NG, Mastaglia F, Goetz C, Pappert E, Small GW, Masterman D, Haines JL, Davies TL.

Neurogenetics · 1999-09-01

DOI: 10.1007/s100480050083PMID: 10541595

Alfa-sinüklein kodlayan gende Ala53Thr mutasyonunu taşıyan Parkinson hastalığı olan ailelerin genetik analizi.

Genetic analysis of families with Parkinson disease that carry the Ala53Thr mutation in the gene encoding alpha-synuclein.

Athanassiadou A, Voutsinas G, Psiouri L, Leroy E, Polymeropoulos MH, Ilias A, Maniatis GM, Papapetropoulos T.

Am J Hum Genet · 1999-08-01

DOI: 10.1086/302486PMID: 10417297

alfa-sinüklein fibrillogenezi nükleasyona bağımlıdır. Parkinson hastalığının patogenezi için implikasyonlar.

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease.

Wood SJ, Wypych J, Steavenson S, Louis JC, Citron M, Biere AL.

J Biol Chem · 1999-07-01

DOI: 10.1074/jbc.274.28.19509PMID: 10391881

[alpha-Synuclein and familial Parkinson's disease].

Iwatsubo T.

No To Shinkei · 1999-06-01

PMID: 10423749

Belirli bir kombine alfa-sinüklein / apolipoprotein E genotipi ile sporadik Parkinson hastalığına duyarlılığın artması.

Increased susceptibility to sporadic Parkinson's disease by a certain combined alpha-synuclein/apolipoprotein E genotype.

Krüger R, Vieira-Saecker AM, Kuhn W, Berg D, Müller T, Kühnl N, Fuchs GA, Storch A, Hungs M, Woitalla D, Przuntek H, Epplen JT, Schöls L, Riess O.

Ann Neurol · 1999-05-01

DOI: 10.1002/1531-8249(199905)45:5<611::aid-ana9>3.0.co;2-xPMID: 10319883

Parkinson hastalığında substantia nigra ve kortekste alfa-sinüklein ekspresyonu.

Alpha-synuclein expression in substantia nigra and cortex in Parkinson's disease.

Neystat M, Lynch T, Przedborski S, Kholodilov N, Rzhetskaya M, Burke RE.

Mov Disord · 1999-05-01

DOI: 10.1002/1531-8257(199905)14:3<417::aid-mds1005>3.0.co;2-xPMID: 10348463