1.220 makale bulundu

LRRK2 Parkinson hastalığında hiperkolinerjik aktivite.

Hypercholinergic activity in LRRK2 Parkinson's disease.

Bohnen NI, Albin RL.

Lancet Neurol · 2018-02-16

DOI: 10.1016/s1474-4422(18)30073-5PMID: 29456160

Parkinson hastalığının manifesto ve premanifest aşamalarında LRRK2 mutasyonlarının kolinerjik sistem üzerindeki etkisi: kesitsel PET çalışması.

The effect of LRRK2 mutations on the cholinergic system in manifest and premanifest stages of Parkinson's disease: a cross-sectional PET study.

Liu SY, Wile DJ, Fu JF, Valerio J, Shahinfard E, McCormick S, Mabrouk R, Vafai N, McKenzie J, Neilson N, Perez-Soriano A, Arena JE, Cherkasova M, Chan P, Zhang J, Zabetian CP, Aasly JO, Wszolek ZK, McKeown MJ, Adam MJ, Ruth TJ, Schulzer M, Sossi V, Stoessl AJ.

Lancet Neurol · 2018-02-16

DOI: 10.1016/s1474-4422(18)30032-2PMID: 29456161

Parkinson hastalığının G2019S Lrrk2 genetik modelinde Dopamin D2 reseptör aracılı nöroproteksiyon.

Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson's disease.

Tozzi A, Tantucci M, Marchi S, Mazzocchetti P, Morari M, Pinton P, Mancini A, Calabresi P.

Cell Death Dis · 2018-02-12

DOI: 10.1038/s41419-017-0221-2PMID: 29434188

Kadın Parkinson hastalığında LRRK2 mutasyonu olan hastalarda CSF lamba2 konsantrasyonları azalır.

CSF lamp2 concentrations are decreased in female Parkinson's disease patients with LRRK2 mutations.

Klaver AC, Coffey MP, Aasly JO, Loeffler DA.

Brain Res · 2018-02-03

DOI: 10.1016/j.brainres.2018.01.016PMID: 29456132

Parkinson hastalığı: PD ve Crohn hastalığına bağlı LRRK2 varyantları.

Parkinson disease: LRRK2 variants linked to PD and Crohn's disease.

Ridler C.

Nat Rev Neurol · 2018-02-02

DOI: 10.1038/nrneurol.2018.10PMID: 29391585

LRRK2 geninde bir p.G2019S mutasyonu taşıyan Parkinson hastalığı hastasından indüklenmiş pluripotent kök hücre hattı (CSC-41) oluşumu.

Generation of an induced pluripotent stem cell line (CSC-41) from a Parkinson's disease patient carrying a p.G2019S mutation in the LRRK2 gene.

Marote A, Pomeshchik Y, Collin A, Goldwurm S, Lamas NJ, Pinto L, Salgado AJ, Roybon L.

Stem Cell Res · 2018-02-02

DOI: 10.1016/j.scr.2018.01.022PMID: 29414418

LRRK2'deki Parkinson hastalığı ile ilişkili mutasyonlar Rab8a fosforilasyon yoluyla sentrozomal kusurlara neden olur.

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.

Madero-Pérez J, Fdez E, Fernández B, Lara Ordóñez AJ, Blanca Ramírez M, Gómez-Suaga P, Waschbüsch D, Lobbestael E, Baekelandt V, Nairn AC, Ruiz-Martínez J, Aiastui A, López de Munain A, Lis P, Comptdaer T, Taymans JM, Chartier-Harlin MC, Beilina A, Gonnelli A, Cookson MR, Greggio E, Hilfiker S.

Mol Neurodegener · 2018-01-23

DOI: 10.1186/s13024-018-0235-yPMID: 29357897

Erratum: Variable frequency of LRRK2 variants in the Latin American research consortium on the genetics of Parkinson's disease (LARGE-PD), a case of ancestry.

Cornejo-Olivas M, Torres L, Velit-Salazar MR, Inca-Martinez M, Mazzetti P, Cosentino C, Micheli F, Perandones C, Dieguez E, Raggio V, Tumas V, Borges V, Ferraz HB, Rieder CRM, Shumacher-Schuh A, Velez-Pardo C, Jimenez-Del-Rio M, Lopera F, Chang-Castello J, Andreé-Munoz B, Waldherr S, Yearout D, Zabetian CP, Mata IF.

NPJ Parkinsons Dis · 2018-01-19

DOI: 10.1038/s41531-017-0025-1PMID: 29367946

Geleceğe Dönüş: Hücre biyolojisinde ve Parkinson hastalığında LRRK2 sinyalizasyonunu değerlendirmek için yeni hedef doğrulanmış Rab antikorları.

Back to the future: new target-validated Rab antibodies for evaluating LRRK2 signalling in cell biology and Parkinson's disease.

Eyers PA.

Biochem J · 2018-01-05

DOI: 10.1042/bcj20170870PMID: 29305429

Parkinson hastalığı LRRK2 kinaz yol aktivitesini insan nötrofillerinde Rab10 fosforilasyonunu değerlendirerek sorgulamak.

Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils.

Fan Y, Howden AJM, Sarhan AR, Lis P, Ito G, Martinez TN, Brockmann K, Gasser T, Alessi DR, Sammler EM.

Biochem J · 2018-01-02

DOI: 10.1042/bcj20170803PMID: 29127255

fosfoya özgü Rab protein antikorlarının gelişimi <i>in vivo</i> LRRK2 Parkinson hastalığı kinazının aktivitesi.

Development of phospho-specific Rab protein antibodies to monitor <i>in vivo</i> activity of the LRRK2 Parkinson's disease kinase.

Lis P, Burel S, Steger M, Mann M, Brown F, Diez F, Tonelli F, Holton JL, Ho PW, Ho SL, Chou MY, Polinski NK, Martinez TN, Davies P, Alessi DR.

Biochem J · 2018-01-02

DOI: 10.1042/bcj20170802PMID: 29127256

Parkinson Hastalığında Onset'te Yaşla LRRK2 Haplotipi Derneği.

Association of LRRK2 Haplotype With Age at Onset in Parkinson Disease.

Xiao B, Deng X, Ng EY, Allen JC, Lim SY, Ahmad-Annuar A, Tan EK.

JAMA Neurol · 2018-01-01

DOI: 10.1001/jamaneurol.2017.3363PMID: 29131875