1.278 makale bulundu

Alpha-synuclein ferrireductase activity is detectible in vivo, is altered in Parkinson's disease and increases the neurotoxicity of DOPAL.

Alfa-sinüklein ferriredüktaz aktivitesi in vivoda tespit edilebilir, Parkinson hastalığında değiştirilir ve DOPAL'ın nörotoksisitesini arttırır.

McDowall JS, Ntai I, Honeychurch KC, Hart JP, Colin P, Schneider BL, Brown DR.

Mol Cell Neurosci · 2017-08-12

DOI: 10.1016/j.mcn.2017.08.001PMID: 28811225

Alpha-synuclein triggers T-cell response. Is Parkinson's disease an autoimmune disorder?

Alfa-sinüklein T-hücre tepkisini tetikler. Parkinson hastalığı otoimmün bir bozukluk mu?

Bandres-Ciga S, Cookson MR.

Mov Disord · 2017-08-07

DOI: 10.1002/mds.27116PMID: 28782845

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease.

Yeni bileşik PBT434, Parkinson hastalığının birden fazla modelinde demir aracılı nörodejenerasyonu ve alfa-sinüklein toksisitesini önler.

Finkelstein DI, Billings JL, Adlard PA, Ayton S, Sedjahtera A, Masters CL, Wilkins S, Shackleford DM, Charman SA, Bal W, Zawisza IA, Kurowska E, Gundlach AL, Ma S, Bush AI, Hare DJ, Doble PA, Crawford S, Gautier EC, Parsons J, Huggins P, Barnham KJ, Cherny RA.

Acta Neuropathol Commun · 2017-06-28

DOI: 10.1186/s40478-017-0456-2PMID: 28659169

Hypermethylation of Synphilin-1, Alpha-Synuclein-Interacting Protein (SNCAIP) Gene in the Cerebral Cortex of Patients with Sporadic Parkinson's Disease.

Sporadik Parkinson Hastalığı Olan Hastaların Serebral Korteksinde Sinfilin-1, Alfa-Synüklein Etkileşimli Protein (SNCAIP) Geninin Hipermetilasyonu.

Dashtipour K, Tafreshi A, Adler C, Beach T, Chen X, Serrano G, Tashiro S, Wang C.

Brain Sci · 2017-06-27

DOI: 10.3390/brainsci7070074PMID: 28653979

Homozygous alpha-synuclein p.A53V in familial Parkinson's disease.

Ailesel Parkinson hastalığında homozigot alfa-sinüklein p.A53V.

Yoshino H, Hirano M, Stoessl AJ, Imamichi Y, Ikeda A, Li Y, Funayama M, Yamada I, Nakamura Y, Sossi V, Farrer MJ, Nishioka K, Hattori N.

Neurobiol Aging · 2017-06-27

DOI: 10.1016/j.neurobiolaging.2017.05.022PMID: 28666710

Striatal changes underlie MPEP-mediated suppression of the acquisition and expression of pramipexole-induced place preference in an alpha-synuclein rat model of Parkinson's disease.

Loiodice S, McGhan P, Gryshkova V, Fleurance R, Dardou D, Hafidi A, Nogueira da Costa A, Durif F.

J Psychopharmacol · 2017-06-20

DOI: 10.1177/0269881117714051PMID: 28631520

Homologous HSV1 and alpha-synuclein peptides stimulate a T cell response in Parkinson's disease.

Homolog HSV1 ve alfa-sinüklein peptidleri Parkinson hastalığında T hücre yanıtını uyarır.

Caggiu E, Paulus K, Galleri G, Arru G, Manetti R, Sechi GP, Sechi LA.

J Neuroimmunol · 2017-06-15

DOI: 10.1016/j.jneuroim.2017.06.004PMID: 28778441

The Presence of Alpha-Synuclein in Skin from Melanoma and Patients with Parkinson's Disease.

Melanoma ve Parkinson Hastalığı Olan Hastalardan Ciltte Alfa-Synüklein Varlığı.

Rodriguez-Leyva I, Chi-Ahumada E, Mejía M, Castanedo-Cazares JP, Eng W, Saikaly SK, Carrizales J, Levine TD, Norman RA, Jimenez-Capdeville ME.

Mov Disord Clin Pract · 2017-06-01

DOI: 10.1002/mdc3.12494PMID: 30363411

Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease.

Parkinson hastalığında alfa-sinükleinin rolünün araştırılması için hücre modelleri.

Lázaro DF, Pavlou MAS, Outeiro TF.

Exp Neurol · 2017-05-16

DOI: 10.1016/j.expneurol.2017.05.007PMID: 28526239

Alpha-Synuclein mRNA Is Not Increased in Sporadic PD and Alpha-Synuclein Accumulation Does Not Block GDNF Signaling in Parkinson's Disease and Disease Models.

Alpha-Synüklein mRNA, Sporadik PD ve Alpha-Synüklein Akümülasyonunda Artmamıştır Parkinson Hastalığı ve Hastalık Modellerinde GDNF Sinyallemesini Engellemez.

Su X, Fischer DL, Li X, Bankiewicz K, Sortwell CE, Federoff HJ.

Mol Ther · 2017-05-15

DOI: 10.1016/j.ymthe.2017.04.018PMID: 28522034

Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease.

Yeni konformasyon-seçici alfa-sinüklein antikorları, farklı in vitro fibril formlarına karşı yükseldiğinde, Parkinson hastalığında Lewy patolojisinin farklı kalıplarını gösterir.

Covell DJ, Robinson JL, Akhtar RS, Grossman M, Weintraub D, Bucklin HM, Pitkin RM, Riddle D, Yousef A, Trojanowski JQ, Lee VM.

Neuropathol Appl Neurobiol · 2017-05-15

DOI: 10.1111/nan.12402PMID: 28386933

Enteric alpha-synuclein pathology in LRRK2-G2019S Parkinson's disease.

Rouaud T, Clairembault T, Coron E, Neunlist M, Anheim M, Derkinderen P.

Parkinsonism Relat Disord · 2017-05-03

DOI: 10.1016/j.parkreldis.2017.05.001PMID: 28483388