Parkinson Hastalığı ve Metabolitlerin İlişkisinin Çözülmesi: Hedefsiz Metabolomik Teknolojiye Dayalı Tabure ve Plazma Metabolitlerinin Kombine Analizi.

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ObjectiveMetabolomics technology has been widely utilized to uncover the action mechanisms of Parkinson's Disease (PD) and to identify PD-related biomarkers. In this study, we compared plasma and fecal metabolite levels between PD patients and their healthy spouses (HS), aiming to identify the associations of differential metabolites with intestinal inflammation, intestinal barrier function, and clinical characteristics of PD.MethodsUntargeted metabolomics techniques were used to characterize plasma and fecal metabolite profiles. We identified metabolites with elevated plasma levels in PD patients, while no significant differences were observed in fecal samples. Partial correlation analysis was employed to investigate the associations between these metabolites, markers of intestinal inflammation (calprotectin and lactoferrin), markers of intestinal permeability (α-1-antitrypsin and zonulin), and clinical characteristics of PD patients.ResultsThe study identified ten metabolites that were significantly elevated in the plasma of PD patients compared to HS (p ConclusionsThis study identified significant metabolite alterations in PD patients and revealed their associations with intestinal barrier dysfunction and clinical characteristics of the disease.

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