Parkinson Hastalığı Olan Postmenopozal Kadınlarda Üreme Faktörleri ve Postmenopozal Seks Hormonları Derneği.

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AimsTo explore the associations of reproductive factors (RFs) and postmenopausal sex hormone (PSH) with cognitive impairment (CI) in postmenopausal women with PD (PWPD), and to develop a predictive nomogram.MethodsNinety-five PWPD were divided into CI (n = 72; Montreal Cognitive Assessment [MoCA] ResultsShorter reproductive lifespan (RLS) and lower education independently predicted CI in PWPD. Compared with RLS ≥ 39 years, RLS ≤ 32 years (adjusted OR = 12.41, p = 0.011) and 33-38 years (adjusted OR = 8.42, p = 0.008) were associated with significantly higher CI risks. The RLS-CI association remained stable across sensitivity analyses and was more prominent in milder-stage patients. No intergroup PSH differences were observed. A nomogram integrating RLS, education, age, disease duration, and Hoehn and Yahr stage (H&Y stage) demonstrated satisfactory discrimination (AUC = 0.903), calibration, and net benefit.ConclusionShorter RLS independently predicts CI in PWPD, particularly in milder-stage patients, while PSH shows no association. This nomogram may serve as a practical screening tool for CI in PWPD, pending external validation.

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