Association of Reproductive Factors and Postmenopausal Sex Hormones With Cognitive Impairment in Postmenopausal Women With Parkinson's Disease.

Research overview

The text below is the source article’s original abstract under a verified reuse license. cc by

AimsTo explore the associations of reproductive factors (RFs) and postmenopausal sex hormone (PSH) with cognitive impairment (CI) in postmenopausal women with PD (PWPD), and to develop a predictive nomogram.MethodsNinety-five PWPD were divided into CI (n = 72; Montreal Cognitive Assessment [MoCA] ResultsShorter reproductive lifespan (RLS) and lower education independently predicted CI in PWPD. Compared with RLS ≥ 39 years, RLS ≤ 32 years (adjusted OR = 12.41, p = 0.011) and 33-38 years (adjusted OR = 8.42, p = 0.008) were associated with significantly higher CI risks. The RLS-CI association remained stable across sensitivity analyses and was more prominent in milder-stage patients. No intergroup PSH differences were observed. A nomogram integrating RLS, education, age, disease duration, and Hoehn and Yahr stage (H&Y stage) demonstrated satisfactory discrimination (AUC = 0.903), calibration, and net benefit.ConclusionShorter RLS independently predicts CI in PWPD, particularly in milder-stage patients, while PSH shows no association. This nomogram may serve as a practical screening tool for CI in PWPD, pending external validation.

Related topics