Nörodejeneratif bozuklukların tanımlanmasında erken biyobelirteçlerin önemi

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In this datanote we presented the data of 31 iRBD (idiopathic Rapid eye movement (REM) sleep Behaviour Disorder) patients studied throughout three years to assess their eventual phenoconversion to Parkinson’s disease and other established neurodegenerative conditions. iRBD is a prodromal condition involved in the development of neurological pathologies such as Parkinson’s disease. In a previous study we evaluated transcription factor mRNA levels in CD4+ T cells as predictive biomarkers of phenoconversion in iRBD. We demonstrated that among the transcription factors mRNA levels analysed, STAT1, GATA3 and FOXP3 mRNA levels in CD4+ T cells may be used to predict phenoconversion.

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