Sıçanlarda tekrarlanan yönetiminin ardından reserpin bilişsel profili: İlerici bir bellek bozukluğu modeli

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Abstract Contrary to other animal models for Alzheimer’s disease (AD) and related cognitive deficits involving acute memory impairment, the present study was designed to provide an animal model exhibiting a progressive decrease in memory upon repeated administration of reserpine (0.1 mg/kg). In the present study, reserpine was injected daily (once a day for three weeks). Short- and long-term memories were assessed using a Morris water maze on a weekly basis. A novel object recognition test was performed after completion of the treatment (day 21). Animals were decapitated on day 21, and brain samples were stored at -70°C. Impairment of short- and long-term activities (as monitored in the Morris water maze) was not observed until after the first week. Long-term memory was found to be impaired earlier than short-term memory. The novel object recognition test also revealed reserpine-induced impairment of working memory. Neurochemical analysis of the whole brain samples by HPLC-EC showed that repeated administration of reserpine significantly decreased dopamine (p ‘progressive’ animal model of memory impairment. The results could be beneficial for understanding the pathophysiology of Parkinson’s-related memory impairment.

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