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Dissecting the biological impact of <i>GBA1</i> mutations using multi-omics in an isogenic setting

Jerez PÁ, Wild Crea PA, Patel D, Glasstetter LM, Alvarez C, Makarious MB, Lara E, Chen Y, Pantazis CB, Paquette K, Malik L, Nalls MA, Reed X, Singleton AB, Billingsley KJ, Mcdonough JA, Ning G, Skarnes WC, Ryten M, Sidransky E, Cookson MR, Beilina S, Blauwendraat C.

· 2025-06-15

DOI: 10.1101/2025.06.12.656971

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
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A CRISPR-CAS9 high throughput machine-learning platform for modulation of genes involved in Parkinson’s disease-associated PINK1-mitophagy in iPSC-derived dopaminergic neurons

Soutar MPM, Carbone B, Kindalova P, Mehrizi R, Lopes FM, Lam N, Rockliffe A, Braybrook T, Taylor M, Nguyen C, Ducotterd F, Reith AD, Mohamet L, Plun-Favreau H.

· 2025-06-15

DOI: 10.1101/2025.06.10.658840

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
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Modulation of SLP-2 expression protects against alpha-synuclein neuropathology by mitigating mitochondrial dysfunction

Bolduc C, Castelo Rueda MP, Lorente Picón M, Gentile G, Kalvakuri S, Linan VS, Zanon A, Laouafa S, Lang M, Lavdas AA, Gilmozzi V, Bernardo G, Coulombe V, Gora C, Peralta MR, Rioux V, Honisch C, Pramstaller PP, Ruzza P, Ziviani E, Bodmer R, Hicks AA, Parent M, Soliz J, Joseph V, Pichler I, Levesque M.

· 2025-06-15

DOI: 10.1101/2025.06.13.659577

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.

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