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191.034 articles found

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Discovery of a Chiral 2,4-Substituted Pyrrolo[2,3-<i>d</i>]pyrimidine as a Potent, Selective, and Orally Bioavailable LRRK2 Inhibitor.

Moukha-Chafiq O, Malankhanova T, Valiyaveettil J, Gupta V, Kezar H, Zhang S, Nguyen TH, Karyakarte S, Zhang W, Bhakat S, Galemmo RA, Ananthan S, Manuvakhova A, Ross LI, Maddry JA, Bostwick R, Suto MJ, West A, Augelli-Szafran CE.

J Med Chem · 2025-05-12

DOI: 10.1021/acs.jmedchem.4c02473PMID: 40353293

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
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Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2<sup>G2019S</sup> model of Parkinson's disease.

Gaertner Z, Oram C, Schneeweis A, Schonfeld E, Bolduc C, Chen C, Dombeck D, Parisiadou L, Poulin JF, Awatramani R.

Elife · 2025-05-12

DOI: 10.7554/elife.101035PMID: 40353820

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
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Diagnosis, evaluation & management of cognitive disorders in Parkinson's disease: A systematic review.

Pourzinal D, Elgey C, Bailey DX, Yang J, Lehn A, Tinson H, Liddle J, Brooks D, Naismith SL, Shrubsole K, Marsh R, Mitchell LK, Pachana NA, King J, Dissanayaka NN.

Int Psychogeriatr · 2025-05-12

DOI: 10.1016/j.inpsyc.2025.100081PMID: 40360335

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.
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The Parkinson's Disease Composite of Executive Functioning: A Measure for Detecting Cognitive Decline in Clinical Trials.

Young CB, Cholerton B, Smith AM, Shahid-Besanti M, Abdelnour C, Mormino EC, Hu SC, Chung KA, Peterson A, Rosenthal L, Pantelyat A, Dawson TM, Quinn J, Zabetian CP, Montine TJ, Poston KL.

Neurology · 2025-05-12

DOI: 10.1212/wnl.0000000000213648PMID: 40354588

A bibliographic record traceable to Europe PMC. Türkçe başlık: makine çevirisi, editoryal kontrol bekliyor.

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