15.843 articles found

Alpha-synuclein in Parkinson's disease: a villain or tragic hero? A critical view of the formation of α-synuclein aggregates induced by dopamine metabolites and viral infection.

Carmo-Gonçalves P, Coelho-Cerqueira E, de Araujo Lima V, Follmer C.

Expert Rev Neurother · 2023-04-05

DOI: 10.1080/14737175.2023.2196014PMID: 37016954

The role of microglial LRRK2 in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction

Pajarillo E, Kim SH, Digman A, Dutton M, Son D, Aschner M, Lee E.

· 2023-04-04

DOI: 10.1101/2023.04.03.535418

Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson's disease.

Gomes S, Garrido A, Tonelli F, Obiang D, Tolosa E, Martí MJ, Ruiz-Martínez J, Vinagre-Aragón A, Hernandez-Eguiazu H, Croitoru I, Marshall VL, Koenig T, Hotzy C, Hsieh F, Sakalosh M, Tengstrand E, Padmanabhan S, Merchant K, Bruecke C, Pirker W, Zimprich A, Sammler E.

NPJ Parkinsons Dis · 2023-04-04

DOI: 10.1038/s41531-023-00482-4PMID: 37015928

α-Synuclein Preformed Fibrils Bind to β-Neurexins and Impair β-Neurexin-Mediated Presynaptic Organization.

Feller B, Fallon A, Luo W, Nguyen PT, Shlaifer I, Lee AK, Chofflet N, Yi N, Khaled H, Karkout S, Bourgault S, Durcan TM, Takahashi H.

Cells · 2023-04-04

DOI: 10.3390/cells12071083PMID: 37048156

Semi-synthetic CoA-α-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies

Pan B, Gardner S, Schultz K, Perez RM, Deng S, Shimogawa M, Sato K, Rhoades E, Marmorstein R, Petersson EJ.

· 2023-04-03

DOI: 10.1101/2023.04.03.535351

The Anthocyanidin Peonidin Interferes with an Early Step in the Fibrillation Pathway of α-Synuclein and Modulates It toward Amorphous Aggregates.

Verma G, Bhat R.

ACS Chem Neurosci · 2023-04-03

DOI: 10.1021/acschemneuro.2c00726PMID: 37011370

Alpha-Synuclein mRNA Level Found Dependent on L444P Variant in Carriers and Gaucher Disease Patients on Enzyme Replacement Therapy.

Dubiela P, Szymańska-Rożek P, Eljaszewicz A, Lipiński P, Hasiński P, Giersz D, Walewska A, Tynecka M, Moniuszko M, Tylki-Szymańska A.

Biomolecules · 2023-04-03

DOI: 10.3390/biom13040644PMID: 37189391

α-synuclein expression in response to bacterial ligands and metabolites in gut enteroendocrine cells

Hurley MJ, Menozzi E, Koletsi S, Bates R, Gegg ME, Chau K, Blottière HM, Macnaughtan J, Schapira AHV.

· 2023-04-02

DOI: 10.1101/2023.04.02.535274

Unraveling the Complex Interplay between Alpha-Synuclein and Epigenetic Modification.

Sugeno N, Hasegawa T.

Int J Mol Sci · 2023-04-02

DOI: 10.3390/ijms24076645PMID: 37047616

Dysregulated Wnt and NFAT signaling in a Parkinson’s disease LRRK2 G2019S knock-in model

Wetzel A, Lei SH, Liu T, Hughes MP, Peng Y, McKay T, Waddington SN, Grannò S, Rahim AA, Harvey K.

· 2023-04-01

DOI: 10.1101/2023.03.31.535090

Air pollution nanoparticle and alpha-synuclein fibrils synergistically decrease glutamate receptor A1, depending upon nPM batch activity

Zhang H, D'Agostino C, Tulisiak C, Thorwald MA, Bergkvist L, Lindquist A, Meyerdirk L, Schulz E, Becker K, Steiner JA, Cacciottolo M, Kwatra M, Rey NL, Escobar Galvis ML, Ma J, Sioutas C, Morgan TE, Finch CE, Brundin P.

Heliyon · 2023-04-01

Nanoscale imaging of individual amyloid aggregates extracted from brains of Alzheimer and Parkinson patients reveals presence of lipids in α-synuclein but not in amyloid β_1-42 fibrils.

Zhaliazka K, Kurouski D.

Protein Sci · 2023-04-01

DOI: 10.1002/pro.4598PMID: 36823759