SCIENTIFIC LITERATURE · MED

Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson's disease.

Gomes S, Garrido A, Tonelli F, Obiang D, Tolosa E, Martí MJ, Ruiz-Martínez J, Vinagre-Aragón A, Hernandez-Eguiazu H, Croitoru I, Marshall VL, Koenig T, Hotzy C, Hsieh F, Sakalosh M, Tengstrand E, Padmanabhan S, Merchant K, Bruecke C, Pirker W, Zimprich A, Sammler E.

NPJ Parkinsons Dis · 2023-04-04

DOI: 10.1038/s41531-023-00482-4PMID: 37015928

Open accessresearch-article; Journal ArticleOriginal source ↗

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The text below is the source article’s original abstract under a verified reuse license. cc by

Elevated urine bis(monoacylglycerol)phosphate (BMP) levels have been found in gain-of-kinase function LRRK2 G2019S mutation carriers. Here, we have expanded urine BMP analysis to other Parkinson's disease (PD) associated mutations and found them to be consistently elevated in carriers of LRRK2 G2019S and R1441G/C as well as VPS35 D620N mutations. Urine BMP levels are promising biomarkers for patient stratification and potentially target engagement in clinical trials of emerging targeted PD therapies.

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