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SCIENTIFIC LITERATURE · MED

Neuroregeneration in neurodegenerative disorders.

BMC Neurol · 2011-06-23

DOI: 10.1186/1471-2377-11-75PMID: 21699711

Open accessResearch Support, Non-U.S. Gov't; research-article; Review; Journal ArticleOriginal source ↗

Research overview

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BackgroundNeuroregeneration is a relatively recent concept that includes neurogenesis, neuroplasticity, and neurorestoration--implantation of viable cells as a therapeutical approach.DiscussionNeurogenesis and neuroplasticity are impaired in brains of patients suffering from Alzheimer's Disease or Parkinson's Disease and correlate with low endogenous protection, as a result of a diminished growth factors expression. However, we hypothesize that the brain possesses, at least in early and medium stages of disease, a "neuroregenerative reserve", that could be exploited by growth factors or stem cells-neurorestoration therapies.SummaryIn this paper we review the current data regarding all three aspects of neuroregeneration in Alzheimer's Disease and Parkinson's Disease.

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