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SCIENTIFIC LITERATURE · MED

<i>GBA</i>-Associated Synucleinopathies: Prime Candidates for Alpha-Synuclein Targeting Compounds.

Front Cell Dev Biol · 2020-09-25

DOI: 10.3389/fcell.2020.562522PMID: 33102473

Open accessresearch-article; Journal ArticleOriginal source ↗

Research overview

The text below is the source article’s original abstract under a verified reuse license. cc by

With disease-modifying compounds targeting alpha-synuclein available in clinical trials, patient stratification according to alpha-synuclein-specific enrichment strategies is a much-needed prerequisite. Such a scenario will be exemplified for GBA, one major genetic risk factor that is specifically associated with the alpha-synucleinopathies: Parkinson's disease and dementia with Lewy bodies.

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