NeuralCipher Source record
Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease.
DOI: 10.1016/j.neuron.2019.05.035PMID: 31255487
SCIENTIFIC EXPLORATION
Genetics & alpha-synuclein
Explore Parkinson literature by research question and topic.
Parkinson’s diseaseDigital biomarkersGenetics & alpha-synucleinTreatment researchMovement disordersNeuroimagingClinical researchSystematic reviews
RESEARCH GUIDE
Find the source. Evaluate the evidence.
This area groups records using publication titles and source-reported publication types. A thematic match is not clinical guidance or expert assessment. Always consult the original study for methods, sample sizes, findings and limitations.
9.897source-linked publicationsOpen filtered search →
Reading Parkinson genetics and alpha-synuclein research
This literature combines association studies, cellular models, animal experiments and studies using human samples. A gene or molecule in a title does not support an individual conclusion about disease risk or causation. Check the variant, population and hypothesis being investigated in the original paper.
For genetic associations, consider sample size, population characteristics, comparison groups and independent replication. For alpha-synuclein studies, distinguish the material studied and the measurement method. A proposed mechanism and a demonstrated clinical outcome represent different questions. Source-linked searches for LRRK2, GBA and alpha-synuclein can help trace related work without implying that the records establish a personal genetic interpretation.
From the literature
All publications →Open access
Detection and interpretation of shared genetic influences on 42 human traits.
DOI: 10.1038/ng.3570PMID: 27182965
Source record
α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.
DOI: 10.1038/nature14547PMID: 26061766
Open access
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.
DOI: 10.7554/elife.12813PMID: 26824392
Source record
The genetic architecture of Parkinson's disease.
DOI: 10.1016/s1474-4422(19)30287-xPMID: 31521533
Open access
Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein.
DOI: 10.1038/nsmb.3194PMID: 27018801
Source record
α-Synuclein aggregation nucleates through liquid-liquid phase separation.
DOI: 10.1038/s41557-020-0465-9PMID: 32514159
Source record
NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein.
DOI: 10.1126/science.1255555PMID: 26250687
When reading a study
- Identify the publication type and research question.
- Distinguish human, animal and laboratory research.
- Assess results and uncertainty from the original text.
- Check the source for retractions and corrections.