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SCIENTIFIC LITERATURE · MED

Circadian and Sleep Dysfunctions in Neurodegenerative Disorders-An Update.

Front Neurosci · 2021-01-18

DOI: 10.3389/fnins.2020.627330PMID: 33536872

Open accessreview-article; Review; Journal ArticleOriginal source ↗

Research overview

The text below is the source article’s original abstract under a verified reuse license. cc by

Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered and multifactorial. Recent evidence suggests that sleep and circadian disturbances may influence the neurodegenerative processes as well as be their consequence. In this perspective, we provide an update of the current understanding of sleep and circadian dysregulation in Alzheimer's, Parkinson's, and Huntington's diseases.

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