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Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease.

PLoS Biol · 2021-07-20

DOI: 10.1371/journal.pbio.3001331PMID: 34284485

Open accessarticle-commentary; Comment; Journal ArticleOriginal source ↗

Research overview

The text below is the source article’s original abstract under a verified reuse license. cc by

In Parkinson disease (PD), Lewy bodies (LBs) form in the gut or nose and spread into the midbrain. A study in this issue indicates that the spread is due to lysosomes "infected" with prion-like alpha-synuclein (α-syn) transmitting from cell to cell via tunneling nanotubes (TNTs).

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