White Matter Connectivity between Structures of the Basal Ganglia using 3T and 7T.

Research overview

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Analysis of the basal ganglia has been important in investigating the effects of Parkinson's disease as well as treatments for Parkinson's disease. One method of analysis has been using MRI for non-invasively segmenting the basal ganglia, then investigating significant parameters that involve the basal ganglia, such as fiber orientations and positional markers for deep brain stimulation (DBS). Following enhancements to optimizations and improvements to 3T and 7T MRI acquisitions, we utilized Lead-DBS on human connectome project data to automatically segment the basal ganglia of 49 human connectome project subjects, reducing the reliance on manual segmentation for more consistency. We generated probabilistic tractography streamlines between each segmentation pair using 3T and 7T human connectome diffusion data to observe any major differences in tractography streamline patterns that can arise due to tradeoffs from different field strengths and acquisitions. Tractography streamlines generated between basal ganglia structures using 3T images showed less standard deviation in streamline count than using 7T images. Mean tractography streamline counts generated using 3T diffusion images were all higher in count than streamlines generated using 7T diffusion images. We illustrate a potential method for analyzing the structural connectivity between basal ganglia structures, as well as visualize possible differences in probabilistic tractography that can arise from different acquisition protocols.

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