SCIENTIFIC LITERATURE · MED

Serum neurofilament indicates that DBS surgery can cause neuronal damage whereas stimulation itself does not.

Frank A, Bendig J, Schniewind I, Polanski WH, Polanski WH, Sobottka SB, Reichmann H, Akgün K, Ziemssen T, Klingelhoefer L, Falkenburger BH.

Sci Rep · 2022-01-27

DOI: 10.1038/s41598-022-05117-xPMID: 35087088

Open accessClinical Trial; Research Support, Non-U.S. Gov't; research-article; Journal ArticleOriginal source ↗

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Deep brain stimulation (DBS) is a potent symptomatic therapy for Parkinson's disease, but it is debated whether it causes or prevents neurodegeneration. We used serum neurofilament light chain (NFL) as a reporter for neuronal damage and found no difference between 92 patients with chronic STN-DBS and 57 patients on best medical treatment. Serum NFL transiently increased after DBS surgery whereas the initiation of STN stimulation did not affect NFL levels, suggesting that DBS surgery can be associated with neuronal damage whereas stimulation itself is not.

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