NeuralCipher Research overview
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BackgroundParkinson's disease (PD) is the second most common neurodegenerative disorder affecting quality of life. The onset of PD is thought to result from a multifaceted convergence of aging, genetic predisposition, and environmental exposure. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score, a specific measure of inflammation and nutrition, has been identified in the literature. No study has determined whether there are differences in inflammation and nutrition between sporadic and familial forms of PD.MethodsA cross-sectional study was conducted involving 1036 participants from Parkinson's Progression Markers Initiative (PPMI), including sporadic PD (sPD) and familial PD (fPD). Data on demographics (age, sex, race, years of education, BMI, age of onset), clinical characteristics (Hoehn and Yahr Scale, Movement Disorder Society-Unified Parkinson's Disease Rating Scale(MDS-UPDRS) Part III Score, MDS-UPDRS Total Score, Montreal Cognitive Assessment, Epworth Sleepiness Scale Score, Geriatric Depression Scale Score, Rapid Eye Movement(REM) Sleep Behavior Disorder Questionnaire Score, caudate nucleus uptake value on dopamine transporter scan, putamen uptake value on dopamine transporter scan, striatum uptake value on dopamine transporter scan), and laboratory parameters (hemoglobin, lymphocytes, monocytes, neutrophils, platelets, blood glucose, uric acid, total protein, urea nitrogen, and albumin) were collected from all participants. Logistic regression and smooth curve fitting analyses were used to support the research objective.ResultsA total of 1036 patients aged between 29.26 and 85.88 years were included in the analysis. A high HALP level was associated with an increased risk of fPD (per 10 units: OR = 1.18, 95 % CI = 1.07-1.29, P = 0.001), after adjustment for potential confounders. In multivariable logistic regression analyses, the risk of fPD occurring in Q3 was 1.8 times that in the Q1 group (OR = 1.8, 95 % CI = 1.16-2.78, P = 0.009). In addition, the results of the subgroup and sensitivity analysis were robust.ConclusionThis study highlights that HALP levels are associated with an increased risk of fPD, independent of confounders.
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