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Validating large language models against manual information extraction from case reports of drug-induced parkinsonism in patients with schizophrenia spectrum and mood disorders: a proof of concept study.

Schizophrenia (Heidelb) · 2025-03-20

DOI: 10.1038/s41537-025-00601-5PMID: 40113776

Open accessresearch-article; Journal ArticleOriginal source ↗

Research overview

The text below is the source article’s original abstract under a verified reuse license. cc by

In this proof of concept study, we demonstrated how Large Language Models (LLMs) can automate the conversion of unstructured case reports into clinical ratings. By leveraging instructions from a standardized clinical rating scale and evaluating the LLM's confidence in its outputs, we aimed to refine prompting strategies and enhance reproducibility. Using this strategy and case reports of drug-induced Parkinsonism, we showed that LLM-extracted data closely align with clinical rater manual extraction, achieving an accuracy of 90%.

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